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  • Anti-ApoER2 Rabbit antibody

Anti-ApoER2 Rabbit antibody

Cat.#: 169049

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Product Information

  • Product Name
    Anti-ApoER2 Rabbit antibody
  • Documents
  • Description
    ApoER2 Rabbit monoclonal antibody
  • Tested applications
    WB, IP
  • Species reactivity
    Human, Mouse, Rat
  • Alternative names
    MCI1; LRP-8; APOER2; HSZ75190 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: A synthetic peptide of human ApoER2
  • Clonality
    Monoclonal antibody
  • Formulation
    50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
  • Storage instructions
    Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Applications

    WB: 1/1000-1/5000

    IP: 1/20-1/50

  • Validations

    Western blot detection of ApoER2 in CHO-K1,C6 cell lysates using ApoER2 Rabbit mAb(1:500 diluted).Predicted band size:106kDa.Observed band size:130106kDa.

    Western blot detection of ApoER2 in CHO-K1,C6 cell lysates using ApoER2 Rabbit mAb(1:500 diluted).Predicted band size:106kDa.Observed band size:130106kDa.

  • Background
    Swiss-Prot Acc.Q14114.Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. Binds the endoplasmic reticulum resident receptor-associated protein (RAP). Binds dimers of beta 2-glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature. Highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation. May also function as an endocytic receptor. Not required for endocytic uptake of SEPP1 in the kidney which is mediated by LRP2 . Together with its ligand, apolipoprotein E (apoE), may indirectly play a role in the suppression of the innate immune response by controlling the survival of myeloid-derived suppressor cells .
  • References

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"