Anti-Angiotensinogen/SerpinA8 antibody

Anti-Angiotensinogen/SerpinA8 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit polyclonal to Angiotensinogen/SerpinA8

ELISA, WB

Mouse Angiotensinogen / SerpinA8 / AGT

Agt antibody; AGT antibody; AI265500 antibody; AngII antibody; angiotensin I antibody; angiotensin II antibody; angiotensin ll antibody; Angiotensinogen antibody; Angiotensinogen antibody; ANHU antibody; antitrypsin antibody; Aogen antibody; FLJ92595 antibody; FLJ97926 antibody; pre-angiotensinogen antibody; Serpina8 antibody; SERPINA8 antibody; alpha-1 antiproteinase antibody; serine (or cysteine) proteinase inhibitor antibody; ANHU antibody; SERPINA8 antibody; AngI antibody; AngII antibody; Aogen antibody; AI265500 antibody; Serpina8 antibody

Rabbit IgG

Produced in rabbits immunized with purified, recombinant Mouse Angiotensinogen / SerpinA8 / AGT (rM Angiotensinogen / SerpinA8 / AGT; P11859; Met 1-Val 477). Angiotensinogen / SerpinA8 / AGT specific IgG was purified by Mouse Angiotensinogen / SerpinA8 / AGT affinity chromatography.

Polyclonal

0.2 μm filtered solution in PBS with 5% trehalose

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Angiotensinogen, also known as AGT and SerpinA8, is a member of the serpin family. It is an α-2-globulin that is produced constitutively and released into the circulation mainly by the liver. Angiotensinogen is a essential component of the renin-angiotensin system (RAS) and a potent regulator of blood pressure. Angiotensinogen can be schematically considered to consist of a combination of an angiotensin I (Ang I) function, located at the N-terminal end, and the presence of a serpin (serine protease inhibitor) structure at the opposite end. Angiotensinogen is cleaved into three chains: Angiotensin-1 (Ang I), Angiotensin-2 (Ang II), and Angiotensin-3 (Ang III). Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin-2. Angiotensin-1 and angiotensin-2 can be further processed to generate angiotensin-3, angiotensin-4. Angiotensin 1-7 is cleaved from angiotensin-2 by ACE2. Angiotensin-2 acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system. Defects in AGT are associated with susceptibility to essential hypertension and renal tubular dysgenesis (RTD). Several serpins (antithrombin, maspin, pigment epithelial-derived factor, and kallistatin) have been recently shown to exert an antiangiogenic activity, suggesting a common mechanism of endothelial cell proliferation and migration. Angiotensinogen/AGT and its renin-cleaved product, des(Ang I)AGT, are also angiogenesis inhibitors, both in vitro and in vivo at concentrations within the range of those observed in plasma. The Angiotensinogen products, that is angiotensin II and possibly angiotensin II-related products, have been found to act locally in modulating adipose tissue growth in an autocrine/paracrine manner. The transient or chronic overexpression of angiotensinogen in adipose tissue favors lipogenesis in adipocytes and leads to a 'vicious' circle whereby adipose tissue development is further increased.

• Ailhaud G, et al. (2002) Angiotensinogen, adipocyte differentiation and fat mass enlargement. Curr Opin Clin Nutr Metab Care. 5(4): 385-9.
• Corvol P, et al. (2003) Inhibition of angiogenesis: a new function for angiotensinogen and des(angiotensin I)angiotensinogen. Curr Hypertens Rep. 5(2): 149-54.