Anti-ALDH4A1 antibody

Anti-ALDH4A1 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit monoclonal to ALDH4A1

WB, IP

Human ALDH4A1

mitochondrial antibody; Aldh4 antibody; ALDH4 antibody; P5CD antibody; P5CDh antibody; Ahd1 antibody; P5cd antibody; Ahd-1 antibody; P5cdh antibody; Ssdh1 antibody; P5cdhl antibody; P5cdhs antibody; Aldh5a1 antibody; E330022C09 antibody; A930035F14Rik antibody; A930035F14Rik antibody; Ahd1 antibody; Ahd-1 antibody; aldehyde dehydrogenase family 4 member A1 antibody; aldehyde dehydrogenase family 4 member A1 antibody; Aldh4 antibody; ALDH4 antibody; Aldh5a1 antibody; delta-1-pyrroline-5-carboxylate dehydrogenase antibody; delta-1-pyrroline-5-carboxylate dehydrogenase antibody; E330022C09 antibody; mitochondrial antibody; mitochondrial delta-1-pyrroline 5-carboxylate dehydrogenase antibody; P5C dehydrogenase antibody; P5C dehydrogenase antibody; P5CD antibody; P5cd antibody; P5CDh antibody; P5cdh antibody; P5cdhl antibody; P5cdhs antibody; RP11-128M10.1 antibody; RP23-334I5.1 antibody; Ssdh1 antibody

Rabbit IgG

This antibody was obtained from a rabbit immunized with purified, recombinant Human ALDH4A1 (rh ALDH4A1; AAH07581.1; Lys25-Gln563).

Monoclonal

0.2 μm filtered solution in PBS

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

ALDH4A1 is a member of the aldehyde dehydrogenase family. Aldehyde dehydrogenase enzymes function in the metabolism of many molecules including certain fats (cholesterol and other fatty acids) and protein building blocks (amino acids). Additional aldehyde dehydrogenase enzymes detoxify external substances, such as alcohol and pollutants, and internal substances, such as toxins that are formed within cells. ALDH4A1 is expressed abundantly in liver followed by skeletal muscle, kidney, heart, brain, placenta, lung and pancreas. It is a mitochondrial matrix NAD-dependent dehydrogenase which catalyzes the second step of the proline degradation pathway, converting pyrroline-5-carboxylate to glutamate. Defects in ALDH4A1 are the cause of hyperprolinemia type 2 (HP-2). HP-2 is characterized by the accumulation of delta-1-pyrroline-5-carboxylate (P5C) and proline. The disorder may be causally related to neurologic manifestations, including seizures and mental retardation.

• Goodman SI, et al. (1974) Defective hydroxyproline metabolism in type II hyperprolinemia. Biochemical medicine. 10 (4): 329-36.
• Maruyama K, et al. (1994) Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. Gene. 138 (1-2): 171-4.
• Vasiliou V, et al. (2005) Analysis and update of the human aldehyde dehydrogenase (ALDH) gene family. Hum Genomics. 2 (2): 138-43.