Anti-ACP1 antibody

Anti-ACP1 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit Polyclonal to Human ACP1

WB, ELISA, IHC-P, ICC/IF, IF, IP

Human ACP1 / LMW-PTP

4632432E04Rik antibody; Acp1 antibody; ACP1 antibody; Acp-1 antibody; AI427468 antibody; LMW-PTPase antibody; MGC3499 antibody; HAAP antibody; LMW-PTP antibody; LMW-PTP antibody; LMW-PTPase antibody; HAAP antibody; Acp-1 antibody; LMW-PTP antibody; AI427468 antibody; 4632432E04Rik antibody; MGC103115 antibody; MGC111030 antibody; MGC132904 antibody

Rabbit IgG

Produced in rabbits immunized with purified, recombinant Human ACP1 / LMW-PTP . ACP1 / LMW-PTP specific IgG was purified by Human ACP1 / LMW-PTP affinity chromatography.

Polyclonal

0.2 μm filtered solution in PBS

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

The low molecular weight phosphotyrosine phosphatase (LMW-PTP), also known as Acid phosphatase 1 (ACP1), belongs to the low molecular weight phosphotyrosine protein phosphatase family are involved in the regulation of important physiological functions, including stress resistance and synthesis of the polysaccharide capsule. ACP1/LMW-PTP is an enzyme involved in platelet-derived growth factor-induced mitogenesis and cytoskeleton rearrangement. LMW-PTP is able to specifically bind and dephosphorylate activated PDGF receptor, thus modulating PDGF-induced mitogenesis. In vitro, LMW-PTP was found to efficiently dephosphorylate activated FcgammaRIIA and LAT, but not Syk or phospholipase Cgamma2. The overexpression of LMW-PTP inhibited activation of Syk downstream of FcgammaRIIA and reduced intracellular Ca(2+) mobilization. It been demonstrated that LMW-PTP is responsible for FcgammaRIIA dephosphorylation, and is implicated in the down-regulation of cell activation mediated by this ITAM-bearing immunoreceptor. In addition, ACP1 is a highly polymorphic phosphatase that is especially abundant in the central nervous system and is known to be involved in several signal transduction pathways.