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Product Name
Anti-ACBD7 antibody
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Description
Rabbit polyclonal to ACBD7
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Tested applications
ELISA, IHC-P
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Species reactivity
Human ACBD7
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Alternative names
9230116B18Rik antibody; ACBD7 antibody; Acbd7 antibody; acyl-CoA binding domain containing 7 antibody; acyl-CoA-binding domain-containing protein 7 antibody; acyl-CoA-binding domain-containing protein 7 antibody; acyl-Coenzyme A binding domain containing 7 antibody; acyl-Coenzyme A binding domain containing 7 antibody; bA455B2.2 antibody; RP11-455B2.6 antibody; RP23-167G19.3 antibody
- Immunogen
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Isotype
Rabbit IgG
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Preparation
Produced in rabbits immunized with purified, recombinant Human ACBD7 (rh ACBD7; Q8N6N7; Met1-Ile88). ACBD7 specific IgG was purified by Human ACBD7 affinity chromatography.
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Clonality
Polyclonal
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Formulation
0.2 μm filtered solution in PBS
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Storage instructions
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. -
Applications
ELISA:0.1-0.2 μg/mL
This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human ACBD7. The detection limit for Human ACBD7 is < 0.039 ng/well.
IHC-P: 0.05-1 μg/ml
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Validations
ACBD7 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
ACBD7 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
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Background
ACBD7, acyl-CoA-binding domain-containing protein 7, is a small (10 Kd) protein that contains 1 ACB (acyl-CoA-binding) domain. The ACB domain consists of four alpha-helices arranged in a bowl shape with a highly exposed acyl-CoA-binding site. The ligand is bound through specific interactions with residues on the protein, most notably several conserved positive charges that interact with the phosphate group on the adenosine-3'phosphate moiety, and the acyl chain is sandwiched between the hydrophobic surfaces of CoA and the protein. Other proteins containing an ACB domain include: ACBP (acyl-CoA-binding protein), ACBD3, ACBD4, ACBD5, ACBD6.
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References
- Rose TM. et al., 1992, Proc Natl Acad Sci. 89 (23): 11287-91.
- Van Aalten DM. et al., 2001, J Mol Biol. 309 (1): 181-92.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"