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Product Name
ANGPTL7 antibody
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Description
ANGPTL7 Rabbit Polyclonal antibody. Positive WB detected in MCF7 cells, COLO 320 cells, HepG2 cells, Y79 cells. Observed molecular weight by Western-blot: 45 kDa
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Tested applications
ELISA, WB
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Species reactivity
Human, Mouse; other species not tested.
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Alternative names
angiopoietin like 7 antibody; Angiopoietin like factor antibody; Angiopoietin like protein 7 antibody; Angiopoietin related protein 7 antibody; ANGPTL7 antibody; AngX antibody; CDT6 antibody; dJ647M16.1 antibody; RP4 647M16.2 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of ANGPTL7 recombinant protein (Accession Number: NM_021146). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
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Validations
MCF7 cells were subjected to SDS PAGE followed by western blot with Catalog No:108060(ANGPTL7 antibody) at dilution of 1:800
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Background
ANGPTL7, also named as CDT6, is a member of the angiopoietin-like (ANGPTL) family of proteins, which are important regulators of Angiogenesis. It is a secreted 45-kDa glycoprotein that folds into a homotetramer structure linked by disulfide bonds. ANGPTL7 was originally discovered in the stromal layer of the corne, and moderately expressed in the human trabecular meshwork. The chromosomal location of the ANGPTL7 gene (1p36.22) is within the GLC3B locus (1p36.2-1p36.1) of primary congenital glaucoma, supporting ANGPTL7 as a candidate glaucoma gene. ANGPTL7 could have a pathogenic role in glaucoma, and may serve as a potential therapeutic target.
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References
- Comes N, Buie LK, Borrás T. Evidence for a role of angiopoietin-like 7 (ANGPTL7) in extracellular matrix formation of the human trabecular meshwork: implications for glaucoma. Genes to cells : devoted to molecular & cellular mechanisms. 16(2):243-59. 2011.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"