-
Product Name
Human Angiopoietin-2 / ANG2 (His Tag) recombinant protein
- Documents
-
Description
Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.
-
Protein name
Angiopoietin-2
-
Protein short names
ANGIOPOIETIN-2A; ANGPT2; AGPT2; ANGIOPOIETIN 2; ANG2; TIE2-LIGAND; ANGIOPOIETIN-2B; ANG-2
-
Uniprot ID
O15123
-
Gene Name
ANGPT2
-
Source/Expression Host
Human Cells
-
Expression Plasmid/cDNA
A DNA sequence encoding the human ANGPT2 (NP_001138.1) (Lys275-Phe496) was expressed with a polyhistidine tag at the N-terminus.
-
Protein Species
Human
-
Molecular weight
The recombinant human ANGPT2 consists 241 amino acids and predicts a molecular mass of 27.8 kDa.
-
Purity
> 95 % as determined by SDS-PAGE.
-
Activity
Measured by its binding ability in a functional ELISA.
Immobilized human ANGPT2 at 10 μg/ml (100 μl /well) can bind human Tie2-Fch (Cat:503333), The EC50 of human Tie2-Fch (Cat:503333) is 0.1-0.3μg/ml. -
Validations
Human Angiopoietin-2 / ANG2 Protein (His Tag)
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"