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Product Name
Canine Angiopoietin-2 / ANG2 (His Tag) recombinant protein
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Description
Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating angiogenic signals mediated by ANGPT1. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal (By similarity).
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Protein name
Angiopoietin-2
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Protein short names
ANGIOPOIETIN 2; ANG2; AGPT2; ANGPT2; ANGIOPOIETIN-2A; ANG-2; ANGIOPOIETIN-2B; TIE2-LIGAND
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Uniprot ID
A0A8J8
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Gene Name
ANGPT2
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the canine ANGPT2 (NP_001041591.1) (Lys274-Phe495) was expressed with a polyhistidine tag at the N-terminus.
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Protein Species
Canine
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Molecular weight
The recombinant canine ANGPT2 consists 241 amino acids and predicts a molecular mass of 27.8 kDa.
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Purity
> 90 % as determined by SDS-PAGE
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Validations
Canine Angiopoietin-2 / ANG2 Protein (His Tag)
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