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Product Name
ANG Polyclonal Antibody
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Description
Polyclonal antibody to ANG
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Tested applications
IHC, IF
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Species reactivity
Human
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Alternative names
ANG antibody; ALS9 antibody; HEL168 antibody; RAA1 antibody; RNASE4 antibody; RNASE5 antibody; angiogenin antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: Recombinant fusion protein containing a sequence corresponding to amino acids 25-147 of human ANG (NP_001091046.1).
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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Storage instructions
Store at -20℃. Avoid freeze / thaw cycles.
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Applications
IHC 1:50 - 1:200
IF 1:50 - 1:200 -
Validations
Immunofluorescence - ANG Polyclonal Antibody
Immunofluorescence analysis of HeLa cells using ANG antibody . Blue: DAPI for nuclear staining.
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Background
Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"