androgen receptor antibody

androgen receptor antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

androgen receptor Rabbit Polyclonal antibody. Positive IHC detected in human prostate cancer tissue, mouse ovary tissue. Positive WB detected in PC-3 cells, HepG2 cells, LNCaP cells, MCF7 cells, mouse heart tissue, NIH/3T3 cells. Observed molecular weight by Western-blot: 71 kDa,100-110 kDa

ELISA, WB, IHC

Human,Mouse,Rat; other species not tested.

AIS antibody; androgen receptor antibody; DHTR antibody; Dihydrotestosterone receptor antibody; HUMARA antibody; HYSP1 antibody; NR3C4 antibody; SBMA antibody; SMAX1 antibody; TFM antibody

Rabbit IgG

This antibody was obtained by immunization of androgen receptor recombinant protein (Accession Number: NM_000044). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

AR, also named as DHTR and NR3C4, belongs to the nuclear hormone receptor family and NR3 subfamily. AR is a ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. AR is activated, but not phosphorylated, by HIPK3. Defects in AR are the cause of androgen insensitivity syndrome (AIS), previously known as testicular feminization syndrome (TFM), which is an X-linked recessive form of pseudohermaphroditism due end-organ resistance to androgen. Defects in AR are the cause of spinal and bulbar muscular atrophy X-linked type 1 (SMAX1) which also known as Kennedy disease. Defects in AR may play a role in metastatic prostate cancer. Defects in AR are the cause of androgen insensitivity syndrome partial (PAIS) which also known as Reifenstein syndrome. This antibody is a rabbit polyclonal antibody raised against residues near the N terminus of human AR.