Amyloid beta (A4) precursor protein antibody

Amyloid beta (A4) precursor protein antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Amyloid beta (A4) precursor protein Rabbit Polyclonal antibody. Positive WB detected in human brain tissue. Observed molecular weight by Western-blot: 102 kDa

ELISA, WB

Human,Mouse,Rat; other species not tested.

AAA antibody; ABETA antibody; ABPP antibody; AD1 antibody; AICD 50 antibody; AICD 57 antibody; AICD 59 antibody; AID(50) antibody; AID(57) antibody; AID(59) antibody; Amyloid beta A4 protein antibody; amyloid P antibody; APP antibody; APPI antibody; beta Amyloid antibody; CTFgamma antibody; CVAP antibody; Gamma CTF(50) C31 antibody; PN II antibody; PN2 antibody; PreA4 antibody; Protease nexin II antibody; S APP alpha Soluble APP beta antibody

Rabbit IgG

This antibody was obtained by immunization of Amyloid beta (A4) precursor protein recombinant protein (Accession Number: BC004369). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

Aβ derives from APP via proteolytic cleavage by proteases called α-, β- and γ-secretase. The α-secretase cleavage precludes the formation of Aβ, while the β- and γ-cleavages generate APP components with amyloidogenic features. Amyloid beta A4 precursor protein(APP), encoded by APP gene which locate on human chromosome 21q, is a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. APP expressed in all fetal tissues and is pronounced in brain, kidney, heart and spleen, but weak in liver. Defects in APP are the cause of Alzheimer disease type 1 (AD1). This antibody can recogniaze the N-terminus of human APP: Soluble APP-alpha and Soluble APP-beta.

• Xu Y, Wang D, Luo Y. Beta amyloid-induced upregulation of death receptor 6 accelerates the toxic effect of N-terminal fragment of amyloid precursor protein. Neurobiology of aging. 36(1):157-68. 2015.