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  • Amyloid β/A4 Protein Precursor770 (586-595) (human, mouse, rat) peptide

Amyloid β/A4 Protein Precursor770 (586-595) (human, mouse, rat) peptide

Not For Human Use, Lab Use Only.

Cat.#: 313231

Size:
Optional Service: TFA RemovalWhat's this?

Special Price 126.5 USD

Availability: 1-2 weeks
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Product Information

  • Product Name
    Amyloid β/A4 Protein Precursor770 (586-595) (human, mouse, rat) peptide
  • Documents
  • Quantity/Unit
    1 Vial
  • Sequence
    ISYGNDALMP
  • Three letter code
    Ile-Ser-Tyr-Gly-Asn-Asp-Ala-Leu-Met-Pro
  • Length (aa)
    10
  • Peptide Purity (HPLC)
    96.6%
  • Molecular Formula
    C47H73N11O16S
  • Molecular Weight
    1080.23
  • Source
    Synthetic
  • Additional Information
    Amyloid β/A4 Protein Precursor770 (586-595) (human, mouse, rat) also known as APP-derived inhibitory peptide (APP-IP), efficiently inhibited the activity of gelatinase A (matrix metalloproteinase-2 (MMP-2)) (IC50 = 30 nM), whereas its inhibitory activity towards membrane type 1-matrix metalloproteinase was much weaker (IC50 = 2 µM). The decapeptide ISYGNDALMP had poor inhibitory activity towards gelatinase B, matrilysin or stromelysin (IC50 > 10 µM). APP-IP is likely an active site-directed inhibitor of gelatinase A. Clarification of its mode of action might provide a lead for the design of novel anti-cancer drugs that block specific processes of tumor invasion and angiogenesis.
  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
  • About TFA salt

    Trifluoroacetic acid (TFA) is a strong acid, which is commonly used to cleave synthesized peptides from solid-phase resins and is also used to improve HPLC performance in the peptide purification step. By default, custom peptides are delivered as lyophilized TFA salts, and can contain as much as 10-45% TFA.

    TFA in custom peptides can cause inexplicable discrepancies in subsequent assay data. For instance, TFA in nM concentrations has been shown to interfere with cellular assays, inhibiting cellular proliferation in some instances, and increasing cell viability in others . It has also been found to be an unintended allosteric modulator of the glycine receptor, GlyR.

    TFA Removal Service is recommended for:

    • Peptides that will be used in cellular assays
    • Peptides that will be used as APIs or in manufactured products
    • For hydrophilic peptides containing numerous basic residues

Peptide Property

  • Analysed Sequence:H-ISYGNDALMP-OH
  • Chemical Formula:C47H73N11O16S
  • Sequence length:10
  • Extinction coefficient:1280 M-1cm-1
  • GRAVY:0.09
  • Mw average:1080.21
  • Theoretical pI:3.12
  • Data Source:Peptide Property Calculator

GRAVY = grand average of hydropathy

X: Hydrophobic uncharged residues, like F I L M V W A and P

X: Basic residues, like R K H

X: Acidic residues, like D E

X: Polar uncharged residues, like G S T C N Q and Y

• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"