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  • Amyloid β//A4 Protein Precursor770 (667-676) peptide

Amyloid β//A4 Protein Precursor770 (667-676) peptide

Not For Human Use, Lab Use Only.

Cat.#: 313058

Size:
Optional Service: TFA RemovalWhat's this?

Special Price 126.5 USD

Availability: 1-2 weeks
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Product Information

  • Product Name
    Amyloid β//A4 Protein Precursor770 (667-676) peptide
  • Documents
  • Quantity/Unit
    1 Vial
  • Sequence
    SEVKMDAEFR
  • Three letter code
    Ser-Glu-Val-Lys-Met-Asp-Ala-Glu-Phe-Arg
  • Length (aa)
    10
  • Peptide Purity (HPLC)
    97.8%
  • Molecular Formula
    C51H82N14O18S
  • Molecular Weight
    1211.37
  • Source
    Synthetic
  • Additional Information
    The peptide substrate APP (667-676), SEVKMDAEFR, corresponds to the wild-type amyloid precursor protein (APP) β-secretase cleavage site. SEVKMDAEFR has been used for assaying β-secretase activity.
  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
  • About TFA salt

    Trifluoroacetic acid (TFA) is a strong acid, which is commonly used to cleave synthesized peptides from solid-phase resins and is also used to improve HPLC performance in the peptide purification step. By default, custom peptides are delivered as lyophilized TFA salts, and can contain as much as 10-45% TFA.

    TFA in custom peptides can cause inexplicable discrepancies in subsequent assay data. For instance, TFA in nM concentrations has been shown to interfere with cellular assays, inhibiting cellular proliferation in some instances, and increasing cell viability in others . It has also been found to be an unintended allosteric modulator of the glycine receptor, GlyR.

    TFA Removal Service is recommended for:

    • Peptides that will be used in cellular assays
    • Peptides that will be used as APIs or in manufactured products
    • For hydrophilic peptides containing numerous basic residues

Peptide Property

  • Analysed Sequence:H-SEVKMDAEFR-OH
  • Chemical Formula:C51H82N14O18S
  • Sequence length:10
  • Extinction coefficient:0 M-1cm-1
  • GRAVY:-0.9
  • Mw average:1211.34
  • Theoretical pI:4.44
  • Data Source:Peptide Property Calculator

GRAVY = grand average of hydropathy

X: Hydrophobic uncharged residues, like F I L M V W A and P

X: Basic residues, like R K H

X: Acidic residues, like D E

X: Polar uncharged residues, like G S T C N Q and Y

• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"