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Product Name
Human ENSA / Endosulfine alpha (His Tag) recombinant protein
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Description
Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity). Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents.
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Protein name
Alpha-endosulfine
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Protein short names
AI451924; 2610007F17RIK; ENSA; ARPP-19E; 1700020C18RIK; RP11-54A4.10-004; ALPHA-ENDOSULFINE; ENDOSULFINE ALPHA
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Uniprot ID
O43768
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Gene Name
ENSA
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the mature form of human ENSA (O43768-1) (Met1-Glu121) was expressed with a polyhistide tag at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human ENSA consists of 136 amino acids and predicts a molecular mass of 15.2 KDa. It migrates as an approximately 18 KDa band in SDS-PAGE under reducing conditions.
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Purity
> 90 % as determined by SDS-PAGE
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Validations
Human ENSA / Endosulfine alpha Protein (His Tag) SDS-PAGE
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