Alpha E catenin antibody

Alpha E catenin antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Alpha E catenin Mouse Monoclonal antibody. Positive IHC detected in human stomach tissue, human colon tissue. Positive WB detected in NIH/3T3 cells. Observed molecular weight by Western-blot: 95-100 kDa

ELISA, WB, IHC

Human, Mouse; other species not tested.

Alpha E catenin antibody; Cadherin assOCiated protein antibody; CAP102 antibody; Catenin alpha 1 antibody; CTNNA1 antibody

Mouse IgG1

This antibody was obtained by immunization of Alpha E catenin recombinant protein (Accession Number: NM_001324000). Purification method: Protein G purified.

Monoclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

Alpha catenin is an essential component of adherens junctions that connects E-cadherin-β-catenin complexes with the actin cytoskeleton. It also recruits a range of other important proteins to developing intercellular junctions. Three alpha catenins exist in human: alpha-E-catenin, alpha-N-catenin, and alpha-T-catenin, which share substantial amino-acid sequence similarity but have distinct tissue distribution. alpha-E-catenin is ubiquitously expressed, alpha-N-catenin is restricted to neuronal tissue, and alpha-T-catenin is primarily expressed in heart tissue. Reduced levels of alpha-E-catenin protein seem to be characteristic of many different human cancers, including malignant tumours of the breast, colon, stomach, oesophagus, bladder and liver. In addition, the loss of alpha-E-catenin often correlates with the degree of tumour differentiation and metastasis.