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  • alpha-Defensin-6 (Human) peptide

alpha-Defensin-6 (Human) peptide

For research use only. We do not sell to patients.

Cat.#: 318887

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Optional Service: TFA RemovalWhat's this?

Special Price 149 USD

Availability: 4 weeks
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Product Information

  • Product Name
    alpha-Defensin-6 (Human) peptide
  • Documents
  • Quantity/Unit
    1 Vial
  • Sequence
    H-AFTCHCRRSCYSTEYSYGTCTVMGINHRFCCL-OH(Disulfide bonds between Cys4- Cys31, Cys6- Cys20, and Cys10- Cys30)
  • Three letter code
    H-Ala-Phe-Thr-Cys-His-Cys-Arg-Arg-Ser-Cys-Tyr-Ser-Thr-Glu-Tyr-Ser-Tyr-Gly-Thr-Cys-Thr-Val-Met-Gly-Ile-Asn-His-Arg-Phe-Cys-Cys-Leu-OH
  • Length (aa)
    32
  • Peptide Purity (HPLC)
    95.2
  • Molecular Formula
    C156H228N46O46S7
  • Molecular Weight
    3708.2
  • Source
    Synthetic
  • Additional Information
    Cysteine-rich cationic peptide with antiviral activity against HSV infection and a role in N. gonorrhoeae-mediated HIV enhancement. In contrast to the other members of the ƒ-defensin family it shows very low antimicrobial activity against Gram-negative and Gram-positive bacteria. As a biomarker of colon adenocarcinoma it may have utility in colon cancer screening and diagnosis.
  • Storage Guidelines
    Ideally alpha-Defensin-6 (Human) peptide should be stored in a freezer at or below -9C. alpha-Defensin-6 (Human) peptide should be refrigerated after reconstitution. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
  • References
    • Z.Wu et al., J. Pept. Res., 64, 118 (2004)
    • M.J.Nam et al., J. Biol. Chem., 280, 8260 (2005)
    • E.Hazrati et al., J. Immunol., 177, 8658 (2006)
    • A.Szyk et al., Protein Sci., 15, 2749 (2006)
    • M.E.Klotman et al., J. Immunol., 180, 6176 (2008)
  • About TFA salt

    Trifluoroacetic acid (TFA) is a strong acid, which is commonly used to cleave synthesized peptides from solid-phase resins and is also used to improve HPLC performance in the peptide purification step. By default, custom peptides are delivered as lyophilized TFA salts, and can contain as much as 10-45% TFA.

    TFA in custom peptides can cause inexplicable discrepancies in subsequent assay data. For instance, TFA in nM concentrations has been shown to interfere with cellular assays, inhibiting cellular proliferation in some instances, and increasing cell viability in others . It has also been found to be an unintended allosteric modulator of the glycine receptor, GlyR.

    TFA Removal Service is recommended for:

    • Peptides that will be used in cellular assays
    • Peptides that will be used as APIs or in manufactured products
    • For hydrophilic peptides containing numerous basic residues

Peptide Property

  • Analysed Sequence:H-AFTCHCRRSCYSTEYSYGTCTVMGINHRFCCL-OH
  • Chemical Formula:C156H228N46O46S7
  • Sequence length:32
  • Extinction coefficient:4200 M-1cm-1
  • GRAVY:-0
  • Mw average:3708.2
  • Theoretical pI:8.02
  • Data Source:Peptide Property Calculator

GRAVY = grand average of hydropathy

Red: Hydrophobic uncharged residues, like F I L M V W A and P

Blue: Basic residues, like R K H and N-terminal -NH2

Green: Acidic residues, like D E and C-terminal -COOH

Black: Polar uncharged residues, like G S T C N Q and Y

Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"