Alpha B Crystallin antibody

Alpha B Crystallin antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Alpha B Crystallin Rabbit Polyclonal antibody. Positive IHC detected in human eye tissue. Positive WB detected in human heart tissue, mouse heart tissue, mouse skeletal muscle tissue. Positive IP detected in mouse heart tissue. Observed molecular weight by Western-blot: 20-22 kDa

ELISA, WB, IHC, IP

Human,Mouse,Rat; other species not tested.

Alpha B Crystallin antibody; Alpha crystallin B chain antibody; Alpha(B) crystallin antibody; CRYA2 antibody; CRYAB antibody; crystallin antibody; alpha B antibody; CTPP2 antibody; Heat shOCk protein beta 5 antibody; HSPB5 antibody; Rosenthal fiber component antibody

Rabbit IgG

This antibody was obtained by immunization of Alpha B Crystallin recombinant protein (Accession Number: NM_001368245). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

Alpha B-crystallin, encoded by CRYAB gene, is multifunctional, serving as both a major structural protein in the lens and a small heat-shock protein in other tissues in mammals. Alpha B-crystallin may contribute to the transparency and refractive index of the lens. Single nucleotide polymorphisms (SNPs) in the promoter region of CRYAB gene have been associated with in multiple sclerosis. Mutations in the CRYAB gene cause distinct clinical phenotypes including isolated posterior polar cataract, myofibrillar myopathy, cardiomyopathy, or a multisystemic disorder combining all these features. Impairment of alpha-B crystallin dimerization may be relevant to the pathogenesis of these disorders.