Rat PEDF (His Tag) recombinant protein

Cat.#: 501619

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Product Information

  • Product Name
    Rat PEDF (His Tag) recombinant protein
  • Documents
  • Description
    Pigment epithelium-derived factor, also known as PEDF, Serpin F1, and SERPINF1, is a multiple functional protein which has both anti-angiogenic activity and neurotrophic activity at the same time. PEDF is a secreted glycoprotein that belongs to the noninhibitory serpin. It has an alpha/beta core serine-protease inhibitor domain, three major beta-sheets, and ten alpha-helices. PEDF does not inhibit either serine or cysteine proteinases. PEDF exerts diverse physiological activities including anti-angiogenesis, anti-vasopermeability, anti-tumor, and neurotrophic activities. PEDF acts via multiple high affinity ligands and cell receptors. It has been described as a natural angiogenesis inhibitor with neurotrophic and immune-modulation properties. PEDF induces macrophages apoptosis and necrosis through the activation of peroxisome proliferator-activated receptor-gamma by which PEDF could modulate inflammatory reactions in septic shock. It balances angiogenesis in the eye and blocks tumor progression.
  • Protein name
    Alpha-2 antiplasmin
  • Protein short names
    SERPINF1; EPC-1; PIG35; OI6; SDF3; AI195227; PEDF; OI12; RP23-384C18.1; PEDFL
  • Uniprot ID
    Q80ZA3
  • Gene Name
    Serpinf1; Dmrs91; rCG_34442
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the rat Serpinf1 (NP_808788.1) (Met1-Thr418) was expressed with a polyhistidine tag at the C-terminus.
  • Protein Species
    Rat
  • Molecular weight
    The recombinant rat Serpinf1 consists 410 amino acids and predicts a molecular mass of 45.9 kDa.
  • Purity
    > 90 % as determined by SDS-PAGE.
  • Validations

    Rat SerpinF1 / PEDF Protein (His Tag)

    Rat SerpinF1 / PEDF Protein (His Tag)

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"