ALK,CD246 antibody

ALK,CD246 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

ALK,CD246 Mouse Monoclonal antibody. Positive IHC detected in human lymphoma tissue. Positive WB detected in Recombinant protein.

ELISA, IHC, WB

Human; other species not tested.

ALK antibody; ALK tyrosine kinase receptor antibody; ALK antibody; CD246 antibody; Anaplastic lymphoma kinase antibody; CD246 antibody; TFG/ALK antibody

Mouse IgG2a

This antibody was obtained by immunization of ALK,CD246 recombinant protein (Accession Number: NM_004304). Purification method: Protein A purified.

Monoclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

ALK, also named as CD246, is a receptor tyrosine kinase (RTK) that belongs to the protein kinase superfamily. ALK is usually found in the nervous system and appears to play an important role in the normal development and function of the nervous system. ALK was originally identified as part of the NPM (Nucleophosmin)-ALK oncogenic fusion protein, resulting from the (2;5)(p23;q35) translocation that is frequently associated with anaplastic large-cell lymphoma (ALCL). The EML4 (echinoderm microtubule-associated protein-like 4)-ALK fusion protein have been described in non-small-cell lung cancer (NSCLC), this transforming fusion kinase is a promising candidate for a therapeutic target as well as for a diagnostic molecular marker in NSCLC (PMID: 17625570).