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Product Name
ALDH1A2 antibody
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Description
ALDH1A2 Rabbit Polyclonal antibody. Positive WB detected in mouse testis tissue, K-562 cells. Observed molecular weight by Western-blot: 53-57kd
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Tested applications
ELISA, WB
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
ALDH1A2 antibody; RALDH 2 antibody; RALDH(II) antibody; RALDH2 antibody; RALDH2 T antibody; Retinal dehydrogenase 2 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of ALDH1A2 recombinant protein (Accession Number: NM_170696). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
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Validations
mouse testis tissue were subjected to SDS PAGE followed by western blot with Catalog No:107960(ALDH1A2 antibody) at dilution of 1:500
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Background
ALDH1A2(aldehyde dehydrogenase family 1 member A2) is also named as RALDH2(retinal dehydrogenase 2) and belongs to the aldehyde dehydrogenase family. It is a cytosolic homotetramer(56.7 kDa subunits) exhibiting complex expression patterns throughout embryonic development. ALDH1A2 plays a role in retinoid metabolism during embryonic development where it is considered to be the major retinoic acid-synthesizing enzyme during early embryogenesis(PMID:20735668). Its expression is reduced in primary prostate tumors compared with normal prostate tissue suggested that it is normally expressed in the epithelial compartment of prostate tissue(PMID:16166285).It has 2 isoforms produced by alternative splicing.
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References
- Bilbija D, Haugen F, Sagave J. Retinoic acid signalling is activated in the postischemic heart and may influence remodelling. PloS one. 7(9):e44740. 2012.
- Arnold SL, Kent T, Hogarth CA. Importance of ALDH1A enzymes in determining human testicular retinoic acid concentrations. Journal of lipid research. 56(2):342-57. 2015.
- Kent T, Arnold SL, Fasnacht R. ALDH Enzyme Expression Is Independent of the Spermatogenic Cycle, and Their Inhibition Causes Misregulation of Murine Spermatogenic Processes. Biology of reproduction. 94(1):12. 2016.
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