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AKT2 antibody

Cat.#: 107949

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Product Information

  • Product Name
    AKT2 antibody
  • Documents
  • Description
    AKT2 Rabbit Polyclonal antibody. Positive IHC detected in human liver tissue, human breast cancer tissue, human liver cancer tissue, human ovary tumor tissue. Positive IP detected in HepG2 cells. Observed molecular weight by Western-blot: 56 kDa
  • Tested applications
    ELISA, IHC, IP
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    AKT2 antibody; PKB beta antibody; PKBB antibody; PKBBETA antibody; PRKBB antibody; Protein kinase Akt 2 antibody; Protein kinase B beta antibody; RAC BETA antibody; RAC PK beta antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of AKT2 recombinant protein (Accession Number: BC063421). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    IP: 1:200-1:2000

    IHC: 1:20-1:200

  • Validations

    Immunohistochemical of paraffin-embedded human liver using Catalog No:107949(AKT2 antibody) at dilution of 1:100 (under 10x lens)

    Immunohistochemical of paraffin-embedded human liver using Catalog No:107949(AKT2 antibody) at dilution of 1:100 (under 10x lens)

    Immunohistochemical of paraffin-embedded human liver using Catalog No:107949(AKT2 antibody) at dilution of 1:100 (under 40x lens)

    Immunohistochemical of paraffin-embedded human liver using Catalog No:107949(AKT2 antibody) at dilution of 1:100 (under 40x lens)

    IP Result of anti-AKT2 (IP:Catalog No:107949, 4ug; Detection:Catalog No:107949 1:500) with HepG2 cells lysate 1600ug.

    IP Result of anti-AKT2 (IP:Catalog No:107949, 4ug; Detection:Catalog No:107949 1:500) with HepG2 cells lysate 1600ug.

  • Background
    AKT2 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis and their activation has been observed in a wide variety of cancers. AKT2 is mainly involved in cancer cell survival, apoptosis inhibition, migration and invasion(PMID:21979951). Defects in AKT2 are a cause of susceptibility to breast cancer (BC). AKT2 promotes metastasis of tumor cells without affecting the latency of tumor development. And defects in AKT2 are a cause of non-insulin-dependent diabetes mellitus (NIDDM) and hypoinsulinemic hypoglycemia with hemihypertrophy (HIHGHH). The full length protein has four glycosylation sites.
  • References
    • Wu L, Chen J, Ding C. MicroRNA-137 Contributes to Dampened Tumorigenesis in Human Gastric Cancer by Targeting AKT2. PloS one. 10(6):e0130124. 2015.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"