AFF4 antibody

AFF4 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

AFF4 Rabbit Polyclonal antibody. Positive WB detected in L02 cells, HeLa cells, HepG2 cells. Positive IP detected in HepG2 cells. Observed molecular weight by Western-blot: 140kd

ELISA, WB, IP

Human,Mouse,Rat; other species not tested.

AF4/FMR2 family member 4 antibody; AF4/FMR2 family antibody; member 4 antibody; AF5Q31 antibody; AFF4 antibody; MCEF antibody; Protein AF 5q31 antibody

Rabbit IgG

This antibody was obtained by immunization of AFF4 recombinant protein (Accession Number: BC063007). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

Transcriptional controled by RNA polymerase II (Pol II) is a multi-step process requiring the concerted action of multiple factors and contacts with the DNA template for the proper synthesis of nascent RNA [PMID:12676794]. ELL1 was demonstrated to be a Pol II elongation factor capable of enhancing the catalytic rate of transcription elongation by reducing transient pausing by the enzyme [PMID:8596958]. AFF4 was initially identified as a fusion partner of the MLL (mixed-lineage leukemia) gene participated in infant acute lymphoblastic leukemia, and a component of the ELL/p-TEFb elongation complex. AFF4 interacts with positive transcription elongation factor-b while also repressing Tat transactivation of HIV-1 [PMID:17389929].