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Product Name
AEBP2 antibody
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Description
AEBP2 Rabbit Polyclonal antibody. Positive WB detected in human testis tissue. Positive IP detected in mouse testis tissue. Observed molecular weight by Western-blot: 52 kDa
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Tested applications
ELISA, WB, IP
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
AE binding protein 2 antibody; AEBP2 antibody; Zinc finger protein AEBP2 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of AEBP2 recombinant protein (Accession Number: BC015624). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:1000
IP: 1:200-1:1000
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Validations
human testis tissue were subjected to SDS PAGE followed by western blot with Catalog No:107898(AEBP2 antibody) at dilution of 1:100
IP Result of anti-AEBP2 (IP:Catalog No:107898, 4ug; Detection:Catalog No:107898 1:300) with mouse testis tissue lysate 4800ug.
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Background
AEBP2, also named as Zinc finger protein AEBP2 or Adipocyte enhancer-binding protein 2, is a 517 amino acid protein, which contains 3 C2H2-type zinc fingers and belongs to the AEBP2/jing C2H2-type zinc-finger family. AEBP2 as a DNA-binding transcriptional repressor may interact with and stimulate the activity of the PRC2 complex, which methylates 'Lys-9' and 'Lys-27' residues of histone H3. It may e playing a role in craniofacial and digital development, as well as development of the central nervous system and gastrointestinal tract.
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References
- Kim H, Kang K, Kim J. AEBP2 as a potential targeting protein for Polycomb Repression Complex PRC2. Nucleic acids research. 37(9):2940-50. 2009.
- Kim H, Kang K, Ekram MB, Roh TY, Kim J. Aebp2 as an epigenetic regulator for neural crest cells. PloS one. 6(9):e25174. 2011.
- Wu H, D'Alessio AC, Ito S. Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells. Nature. 473(7347):389-93. 2011.
- Holdt LM, Hoffmann S, Sass K. Alu elements in ANRIL non-coding RNA at chromosome 9p21 modulate atherogenic cell functions through trans-regulation of gene networks. PLoS genetics. 9(7):e1003588. 2013.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"