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Product Name
ADI1 antibody
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Description
ADI1 Rabbit Polyclonal antibody. Positive IHC detected in human colon cancer tissue. Positive WB detected in human testis tissue, rat colon tissue. Observed molecular weight by Western-blot: 20 kDa
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Tested applications
ELISA, WB, IHC
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
Aci reductone dioxygenase antibody; acireductone dioxygenase 1 antibody; ADI1 antibody; APL1 antibody; ARD antibody; FLJ10913 antibody; HMFT1638 antibody; MTCBP 1 antibody; MTCBP1 antibody; SIP L antibody; SIPL antibody
- Immunogen
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of ADI1 recombinant protein (Accession Number: NM_018269). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
IHC: 1:20-1:200
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Validations
human testis tissue were subjected to SDS PAGE followed by western blot with Catalog No:107793(ADI1 antibody) at dilution of 1:400
Immunohistochemical of paraffin-embedded human colon cancer using Catalog No:107793(ADI1 antibody) at dilution of 1:100 (under 10x lens)
Immunohistochemical of paraffin-embedded human colon cancer using Catalog No:107793(ADI1 antibody) at dilution of 1:100 (under 40x lens)
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Background
ADI1(acireductone dioxygenase 1 ) is also named as SIPL, ARD, APL1, HMFT1638, MTCBP-1, FLJ10913, MTCBP1 and belongs to the acireductone dioxygenase (ARD) family. It catalyzes the formation of formate and 2-keto-4-methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).The downregulation of ADI1 protein expression in human prostate cancer specimens argues that ADI1 potentially inhibits the growth that occurs during prostate cancer progression(PMID:17786183). It has 2 isoforms produced by alternative splicing.
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