ADI-65534 antibody

ADI-65534 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

ADI 65534 an neutralizing antibody against ANDV (New World Hantavirus) and PUUV (Old World Hantavirus)

Human IgG

Recombinant expression and purified from CHO cells.

Monoclonal

Lyophilized, PBS(pH7.2)

Store at -20℃. Avoid freeze / thaw cycles.

ADI-65534 is an engineered antibody variant derived from the pan-hantavirus protective antibody ADI-42898. It was designed to enhance the potency and cross-clade neutralization of the original antibody, particularly against the highly lethal Andes virus (ANDV). ADI-65534 was developed through affinity maturation of ADI-42898, resulting in improved binding affinity and reduced dissociation at acidic pH, which is crucial for its activity against ANDV. It recognizes a quaternary epitope spanning the Gn and Gc subunits of the hantavirus glycoprotein complex, locking the Gn/Gc heterodimer in its prefusion conformation and preventing membrane fusion, a critical step in viral entry. ADI-65534 maintains the broad-spectrum activity of its parent antibody, ADI-42898, and is effective against both Old World and New World hantaviruses.