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Product Name
Human AMIGO2 / AMIGO-2 / alivin 1 (His Tag) recombinant protein
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Description
TMEM27 is a membrane protein. It has been proposed as a beta cell mass biomarker since it is cleaved and shed by pancreatic beta cells. Overexpression of TMEM27 leads to increased thymidine incorporation, whereas silencing of Tmem27 using RNAi results in a reduction of cell replication. Furthermore, transgenic mice with increased expression of Tmem27 in pancreatic beta cells exhibit increased beta cell mass. TMEM27 is also important for trafficking amino acid transporters to the apical brush border of proximal tubules.
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Protein name
Adhesion molecule with Ig-like domain 2, isoform CRA_a
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Protein short names
RP23-59N7.2; NX17; NX-17; KIDNEY-SPECIFIC MEMBRANE PROTEIN; UNQ679/PRO1312; 0610008J07RIK; COLLECTRIN
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Uniprot ID
Q86SJ2
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Gene Name
AMIGO2; hCG_1640635
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human AMIGO2 (NP_862830.1) (Met1-Thr398) was expressed with a polyhistidine tag at the C-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human AMIGO2 consists of 370 amino acids and predicts a molecular mass of 42.3 KDa. It migrates as an approximately 58-63 KDa band in SDS-PAGE under reducing conditions.
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Purity
> 95 % as determined by SDS-PAGE
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Validations
Human AMIGO2 Protein (His Tag) SDS-PAGE
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"