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Product Name
ADAM17 antibody
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Description
ADAM17 Rabbit Polyclonal antibody. Positive WB detected in U-937 cells. Positive IHC detected in human pancreas cancer tissue. Observed molecular weight by Western-blot: 75 kDa
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Tested applications
ELISA, WB, IHC
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Species reactivity
Human; other species not tested.
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Alternative names
ADAM 17 antibody; ADAM17 antibody; CD156b antibody; cSVP antibody; Snake venom like protease antibody; TACE antibody; TNF alpha convertase antibody; TNF alpha converting enzyme antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of ADAM17 recombinant protein (Accession Number: NM_003183). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
IHC: 1:20-1:200
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Validations
U-937 cells were subjected to SDS PAGE followed by western blot with Catalog No:107762(ADAM17 Antibody) at dilution of 1:600
Immunohistochemistry of paraffin-embedded human pancreas cancer tissue slide using Catalog No:107762(ADAM17 Antibody) at dilution of 1:200 (under 10x lens).
Immunohistochemistry of paraffin-embedded human pancreas cancer tissue slide using Catalog No:107762(ADAM17 Antibody) at dilution of 1:200 (under 40x lens).
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Background
The ADAMs (A Disintegrin And Metalloprotease) are multidomain transmembrane proteins. One of the first ADAMs implicated in membrane shedding is ADAM-17, which is shown to release the active form of tumor necrosis factor (TNF)-a from its precursor(PMID:18238782). ADAM17 is also named as CSVP, TACE. The full length protein has 9 glycosylation sites, a signal peptide, propeptide and 2 isoforms produced by alternative splicing.The 120-kDa form of ADAM-17 is expressed more frequently and at higher levels in primary breast carcinomas compared with normal breast tissue(PMID:17438092).
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