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Human ACVR2A (Fc Tag) recombinant protein

Cat.#: 502084

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Product Information

  • Product Name
    Human ACVR2A (Fc Tag) recombinant protein
  • Documents
  • Description
    On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.
  • Protein name
    Activin receptor type-2A
  • Protein short names
    ACVR2; TACTRII; ACVR2A; RP23-139F8.3; ACTRIIA; ACTRII
  • Uniprot ID
    P27037
  • Gene Name
    ACVR2A; ACVR2
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the N-terminal segment (Met 1-Pro 134) from the extracellular domain of human ACVR2A (NP_001607.1) was fused with the Fc region of human IgG1 at the C-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human ACVR2A/Fc chimera is a disulfide-linked homodimer protein generated after removal of the signal peptide. The monomer comprises 352 amino acids and predicts a molecular mass of 40.0 kDa. As a result of glycosylation, the monomer migrates as an approximately 60-65 kDa protein in SDS-PAGE under reducing conditions.
  • Purity
    > 97 % as determined by SDS-PAGE
  • Activity
    Measured by its ability to neutralize Activin-mediated inhibition on MPC11 cell proliferation.
    The ED50 for this effect is typically 10-40 ng/mL in the presence of 10 ng/mL recombinant Activin A.
  • Validations

    Human ACVR2 / ACTRII / ACVR2A Protein (Fc Tag) SDS-PAGE

    Human ACVR2 / ACTRII / ACVR2A Protein (Fc Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"