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  • α-MSH peptide

α-MSH peptide

Not For Human Use, Lab Use Only.

Cat.#: 315681

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Optional Service: TFA RemovalWhat's this?

Special Price 164.5 USD

Availability: 1-2 weeks
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Product Information

  • Product Name
    α-MSH peptide
  • Documents
  • Sequence Shortening
    SYSMEHFRWGKPV
  • Sequence
    Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val
  • Length (aa)
    13
  • Peptide Purity (HPLC)
    97.6%
  • Molecular Formula
    C75H106N20O19S
  • Molecular Weight
    1623.9
  • CAS No.
    22006-64-0
  • Source
    Synthetic
  • Form
    Powder
  • Description
    Melanocortin receptors (MCRs), MC1R-MC5R, belong to the GPCR super family. MC1R shows the highest expression in melanomas and in the majority of human metastatic melanoma derived tumor cells. MC1R is primarily involved in the skin pigmentation and expressed by normal human skin cells including keratinocytes and melanocytes. Alpha-melanocyte stimulating hormone (α-MSH) (SYSMEHFRWGKPV) is a 13 amino acids long peptide that binds MC1R with high affinity. SAR data from alanine substitution and tyrosinase activity measurement showed that Met4-His6-Phe7-Arg8-Trp9 are important for the binding to melanocortin receptor and biological activity.
  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
  • About TFA salt

    Trifluoroacetic acid (TFA) has a significant impact on peptides due to its role in the peptide synthesis process.

    TFA is essential for the protonation of peptides that lack basic amino acids such as Arginine (Arg), Histidine (His), and Lysine (Lys), or ones that have blocked N-termini. As a result, peptides often contain TFA salts in the final product.

    TFA residues, when present in custom peptides, can cause unpredictable fluctuations in experimental data. At a nanomolar (nM) level, TFA can influence cell experiments, hindering cell growth at low concentrations (as low as 10 nM) and promoting it at higher doses (0.5–7.0 mM). It can also serve as an allosteric regulator on the GlyR of glycine receptors, thereby increasing receptor activity at lower glycine concentrations.

    In an in vivo setting, TFA can trifluoroacetylate amino groups in proteins and phospholipids, inducing potentially unwanted antibody responses. Moreover, TFA can impact structure studies as it affects spectrum absorption.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Peptide Property

  • Analysed Sequence:H-SYSMEHFRWGKPV-OH
  • Chemical Formula:C75H106N20O19S
  • Sequence length:13
  • Extinction coefficient:6970 M-1cm-1
  • GRAVY:-0.92
  • Mw average:1623.82
  • Theoretical pI:9.72
  • Data Source:Peptide Property Calculator

GRAVY = grand average of hydropathy

X: Hydrophobic uncharged residues, like F I L M V W A and P

X: Basic residues, like R K H

X: Acidic residues, like D E

X: Polar uncharged residues, like G S T C N Q and Y

• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"