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Product Name
ACOX1 antibody
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Description
ACOX1 Rabbit Polyclonal antibody. Positive WB detected in mouse kidney tissue, mouse liver tissue. Positive IHC detected in human liver cancer tissue, human lung cancer tissue. Observed molecular weight by Western-blot: 50kd
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Tested applications
ELISA, WB, IHC
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
ACOX antibody; ACOX1 antibody; AOX antibody; PALMCOX antibody; Palmitoyl CoA oxidase antibody; SCOX antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of ACOX1 recombinant protein (Accession Number: NM_004035). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IHC: 1:20-1:200
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Validations
mouse kidney tissue were subjected to SDS PAGE followed by western blot with Catalog No:107749(AOX antibody) at dilution of 1:300
Immunohistochemical of paraffin-embedded human liver cancer using Catalog No:107749(AOX antibody) at dilution of 1:100 (under 10x lens)
Immunohistochemical of paraffin-embedded human liver cancer using Catalog No:107749(AOX antibody) at dilution of 1:100 (under 40x lens)
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Background
ACOX1(Peroxisomal acyl-coenzyme A oxidase 1) is the first and rate-limiting enzyme in the peroxisomal fatty acid beta-oxidation pathway and catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs.It belongs to the acyl-CoA oxidase family and also named as ACOX,AOX,SCOX.It has 2 isoforms produced by alternative splicing and Defects in ACOX1 are the cause of adrenoleukodystrophy pseudoneonatal (Pseudo-NALD).
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References
- Sun X, Tang Y, Tan X. Activation of peroxisome proliferator-activated receptor-γ by rosiglitazone improves lipid homeostasis at the adipose tissue-liver axis in ethanol-fed mice. American journal of physiology. Gastrointestinal and liver physiology. 302(5):G548-57. 2012.
- Haldar SM, Jeyaraj D, Anand P. Kruppel-like factor 15 regulates skeletal muscle lipid flux and exercise adaptation. Proceedings of the National Academy of Sciences of the United States of America. 109(17):6739-44. 2012.
- Kassmann CM, Quintes S, Rietdorf J. A role for myelin-associated peroxisomes in maintaining paranodal loops and axonal integrity. FEBS letters. 585(14):2205-11. 2011.
- Wang Y, Kou Y, Wang X, Cederbaum A, Wang R. Multifactorial comparative proteomic study of cytochrome P450 2E1 function in chronic alcohol administration. PloS one. 9(3):e92504. 2014.
- Li Q, Xie G, Zhang W. Dietary nicotinic acid supplementation ameliorates chronic alcohol-induced fatty liver in rats. Alcoholism, clinical and experimental research. 38(7):1982-92. 2014.
- Guo Y, Zhang X, Huang J. Relationships between hematopoiesis and hepatogenesis in the midtrimester fetal liver characterized by dynamic transcriptomic and proteomic profiles. PloS one. 4(10):e7641. 2009.
- Kamli MR, Kim J, Pokharel S, Jan AT, Lee EJ, Choi I. Expressional studies of the aldehyde oxidase (AOX1) gene during myogenic differentiation in C2C12 cells. Biochemical and biophysical research communications. 450(4):1291-6. 2014.
- Zidek LM, Ackermann T, Hartleben G. Deficiency in mTORC1-controlled C/EBPβ-mRNA translation improves metabolic health in mice. EMBO reports. 16(8):1022-36. 2015.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"