ACK1 antibody

ACK1 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

ACK1 Rabbit Polyclonal antibody. Positive WB detected in SH-SY5Y cells, A431 cells, HeLa cells, HepG2 cells, mouse brain tissue, HT-1080 cells. Positive IHC detected in human breast cancer. Observed molecular weight by Western-blot: 70 kDa

ELISA, WB, IHC

human, mouse, rat; other species not tested.

TNK2 antibody; ACK1 antibody; ACK antibody; FLJ45547 antibody; ACK 1 antibody

Rabbit IgG

This antibody was obtained by immunization of ACK1 recombinant protein (Accession Number: BC028164). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

TNK2, also named as ACK1, belongs to the protein kinase superfamily and Tyr protein kinase family. It is a non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. TNK2 transduces extracellular signals to cytosolic and nuclear effectors. It is a downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. TNK2 confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR. The 60-70kd band is the isoform 2 of TNK2. Isoform 1 and 3 is about 120-125kd.