• Acetyl Tetrapeptide-3 (TFA removed)

Acetyl Tetrapeptide-3 (TFA removed)

Not For Human Use, Lab Use Only.

Cat.#: 319566

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Special Price 84.0 USD

Availability: 1-2 weeks
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Product Information

  • Product Name
    Acetyl Tetrapeptide-3 (TFA removed)
  • Documents
  • Sequence
    Ac-KGHK-NH2
  • Three letter code
    Ac-Lys-Gly-His-Lys-NH2
  • Length (aa)
    4
  • Peptide Purity (HPLC)
    97.94%
  • Molecular Formula
    C22H39N9O5
  • Molecular Weight
    509.6
  • Source
    Synthetic
  • Additional Information
    Acetyl tetrapeptide-3 is a biomimetic peptide derived from a growth factor, also known by the trading name Folixyl®. It has a sequence Ac-Lys-Gly-His-Lys-NH2 (KGHK) specially designed to fight the symptoms of hair loss and stimulate hair growth. With its ability to stimulate the synthesis of follicle extracellular matrix proteins (Collagen I and III, laminin), Acetyl tetrapeptide-3 helps the renewal of dermal papilla cells and opposes the stiffening of the sheath of the hair follicle that causes hair loss. Tests on human hair follicles showed that Acetyl tetrapeptide-3 stimulates hair growth. Compared with Minoxidil, a reference in hair growth treatment, Folixyl® was superior in regards to the percentage of hair growth after 7 days of treatment.
  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
  • References
    • Lueangarun S, Panchaprateep R. An Herbal Extract Combination (Biochanin A, Acetyl tetrapeptide-3, and Ginseng Extracts) versus 3% Minoxidil Solution for the Treatment of Androgenetic Alopecia: A 24-week, Prospective, Randomized, Triple-blind, Controlled Trial. J Clin Aesthet Dermatol. 2020 Oct;13(10):32-37. Epub 2020 Oct 1.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a strong acid, which is commonly used to cleave synthesized peptides from solid-phase resins and is also used to improve HPLC performance in the peptide purification step. By default, custom peptides are delivered as lyophilized TFA salts, and can contain as much as 10-45% TFA.

    TFA in custom peptides can cause inexplicable discrepancies in subsequent assay data. For instance, TFA in nM concentrations has been shown to interfere with cellular assays, inhibiting cellular proliferation in some instances, and increasing cell viability in others . It has also been found to be an unintended allosteric modulator of the glycine receptor, GlyR.

    TFA Removal Service is recommended for:

    • Peptides that will be used in cellular assays
    • Peptides that will be used as APIs or in manufactured products
    • For hydrophilic peptides containing numerous basic residues

  • Molar Concentration Calculator

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  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"