• Ac-SDKP peptide

Ac-SDKP peptide

Not For Human Use, Lab Use Only.

Cat.#: 319303

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Optional Service: TFA RemovalWhat's this?

Special Price 94.2 USD

Availability: 1-2 weeks
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Product Information

  • Product Name
    Ac-SDKP peptide
  • Documents
  • Sequence
    Ac-SDKP-OH
  • Three letter code
    Ac-Ser-Asp-Lys-Pro-OH
  • Length (aa)
    4
  • Peptide Purity (HPLC)
    95.07%
  • Molecular Formula
    C20H33N5O9
  • Molecular Weight
    487.5
  • Source
    Synthetic
  • Additional Information
    Ac-SDKP is a natural tetrapeptide with anti-inflammatory and antifibrotic properties. It has been widely distributed in mammalian organs, plasma, urine, and circulating mononuclear cells. The peptide is hydrolyzed by angiotensin-converting enzyme (ACE) and has a short half-life of 4.5 min in the circulation. Treatment with ACE inhibitors significantly increases plasma concentration of Ac-SDKP, and some of the ACE inhibitors protective effects were reported to be mediated by the increases in Ac-SDKP concentrations. In animal diseases with hypertension, as well as cardiovascular and kidney disease, Ac-SDKP reduces inflammatory cell infiltration and collagen deposition in the heart, kidney, lung, and liver. The peptide has potential applications in the treatment of various inflammatory and fibrotic diseases.
  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
  • References
    • Kumar N, Nakagawa P, Janic B, Romero CA, Worou ME, Monu SR, Peterson EL, Shaw J, Valeriote F, Ongeri EM, Niyitegeka JM, Rhaleb NE, Carretero OA. The anti-inflammatory peptide Ac-SDKP is released from thymosin-β4 by renal meprin-α and prolyl oligopeptidase. Am J Physiol Renal Physiol. 2016 May 15;310(10):F1026-34. doi: 10.1152/ajprenal.00562.2015. Epub 2016 Mar 9. PMID: 26962108; PMCID: PMC4889319.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a strong acid, which is commonly used to cleave synthesized peptides from solid-phase resins and is also used to improve HPLC performance in the peptide purification step. By default, custom peptides are delivered as lyophilized TFA salts, and can contain as much as 10-45% TFA.

    TFA in custom peptides can cause inexplicable discrepancies in subsequent assay data. For instance, TFA in nM concentrations has been shown to interfere with cellular assays, inhibiting cellular proliferation in some instances, and increasing cell viability in others . It has also been found to be an unintended allosteric modulator of the glycine receptor, GlyR.

    TFA Removal Service is recommended for:

    • Peptides that will be used in cellular assays
    • Peptides that will be used as APIs or in manufactured products
    • For hydrophilic peptides containing numerous basic residues

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Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"