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Product Name
ABCD1 antibody
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Description
ABCD1 Rabbit Polyclonal antibody. Positive IF detected in HeLa cells. Positive IHC detected in human lung cancer tissue. Positive IP detected in mouse liver tissue. Positive WB detected in human brain tissue, HeLa cells, mouse liver tissue. Observed molecular weight by Western-blot: 75 kDa
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Tested applications
ELISA, WB, IHC, IP, IF
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
ABC42 antibody; ABCD1 antibody; Adrenoleukodystrophy protein antibody; ALD antibody; ALDP antibody; AMN antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of ABCD1 recombinant protein (Accession Number: NM_000033). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IP: 1:200-1:2000
IHC: 1:20-1:200
IF: 1:20-1:200
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Validations
human brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:107801(ABCD1 antibody) at dilution of 1:300
IP Result of anti-ABCD1 (IP:Catalog No:107801, 4ug; Detection:Catalog No:107801 1:500) with mouse liver tissue lysate 5000ug.
Immunohistochemical of paraffin-embedded human lung cancer using Catalog No:107801(ABCD1 antibody) at dilution of 1:50 (under 10x lens)
Immunofluorescent analysis of HeLa cells using Catalog No:107801(ABCD1 Antibody) at dilution of 1:50 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Background
ABCD1 (also known as ALDP) is a member of the ATP-binding cassette (ABC) transporter superfamily which functions as transporter for a wide variety of substrates. It localizes to the peroxisomal membrane. The exact function is not clear so far. Various mutations of ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), an inherited neurodegenerative disease affecting the nervous system white matter and adrenal cortex.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"