2019-nCoV Papain-Like Protease

Cat.#: 521005

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Product Information

  • Product Name
    2019-nCoV Papain-Like Protease
  • Documents
  • Description
    Replication of severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) requires proteolytic processing of the replicase polyprotein by two viral cysteine proteases, a chymotrypsin-like protease (3CLpro) and a papain-like protease (PLpro). These proteases are important targets for development of antiviral drugs that would inhibit viral replication and reduce mortality associated with outbreaks of SARS-CoV. PLpro is a cysteine protease located within the non-structural protein 3 (NS3) section of the viral polypeptide. PLPro activity is required to process the viral polyprotein into functional, mature subunits; specifically, PLPro cleaves a site at the amino-terminus of the viral replicase region. In addition to its role in viral protein maturation, PLPro possesses a deubiquitinating and deISGylating activity. In vivo, this protease antagonizes innate immunity by inhibiting IRF3-induced production of type I interferons.
  • Protein short names
    Papain-like Protease; PLpro; PL-PRO; pp1a; Replicase polyprotein 1a
  • Uniprot ID
    QHD43415.1
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    Target gene encoding Glu1564-Lys1878 was expressed in E.coli
  • Protein Species
    Severe acute respiratory syndrome coronavirus 2
  • Molecular weight
    35.8kDa
  • Purity
    >90%
  • Activity
    Measured by its ability to cleave a fluorogenic peptide substrate, (E-EDANS)RELNGGAPI(K-DABCYL)S (Synthetic).
    The specific activity is >2000pmoi/min/mg.
  • Validations

    2019-nCoV Papain-Like Protease

    2019-nCoV Papain-Like Protease

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"