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Product Name
Mouse 14-3-3 sigma/Stratifin/YWHAS recombinant protein
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Description
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53.
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Protein name
14-3-3 protein sigma
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Protein short names
14-3-3 SIGMA; ER; RP23-137L22.11; MME1; STRATIFIN; YWHAS
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Uniprot ID
O70456
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Gene Name
Sfn; Mkrn3
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the mouse SFN (NP_061224.2) (Met 1-Ser 248) was expressed and purified, with additional two amino acids (Gly & Pro) at the N-terminu.
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Protein Species
Mouse
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Molecular weight
The recombinant mouse SFN consists of 250 amino acids and has a calculated molecular mass of 27.7 kDa. It migrates as an approximately 32 kDa band in SDS-PAGE under reducing conditions.
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Purity
> 95 % as determined by SDS-PAGE
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Validations
Mouse 14-3-3 sigma / Stratifin / YWHAS Protein SDS-PAGE
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