Introduction:
Since the hypothesis put forward, there is a lot of research results to support it provides, but also raises some questions. In this review, the authors evaluated the support and opposition ceRNA hypothesis is some evidence, and the effect of endogenous miRNA sponges (miRNA sponge) interacting.
ceRNA (competitive endogenous RNA, within a competitive source of RNA) hypothesis proposed in 2011 by the Harvard Medical School, Pier Paolo Pandolfi research group, which is a regulation of gene expression patterns, refers to the reaction between the mRNA can originals (MREs) by miRNAs reach Modulation of purpose.
Competing endogenous RNA mechanism (from: Nature Reviews Genetics)
ceRNA hypothesis put forward given the mRNA and non-coding RNA new, more extensive biological functions. Between the various types of RNA by RNA-RNA regulatory network consisting dialogue play a role in the biological and pathophysiological processes. Currently ceRNA including mRNA, pseudogene transcript, long non- coding RNA (lncRNA) and cyclic RNA (circRNA) and the like.
Since the hypothesis put forward, there is a lot of research results to support it provides, but also raises some questions. In this review, the authors evaluated the support and opposition ceRNA hypothesis is some evidence, and the effect of endogenous miRNA sponges (miRNA sponge) interacting.
Summary describes the total of six parts, including artificial miRNA inhibitors (miRNA sponges), the experimental evidence ceRNAs, ceRNA network, a wide range of RNA transcriptome competition, and enhanced model validation ceRNA ceRNA activity restriction. The following is a partial diagram of the article:
The active transcriptome available for microRNA binding competition (From: Nature Reviews Genetics)
Strategies used to assess transcriptome-wide competition for microRNA binding (From: Nature Reviews Genetics）
In conclusion, the authors said the study found evidence ceRNA hypothesis, it has the largest role in the pathology associated with aberrant transcriptome changes in assessment, as well as extensive reconstruction 3'UTRs cancer observed in poly gland glycosides acidification kinetics.
August 2015, published an article on the " genetic " magazine article entitled "The biological function within a competitive source of RNA and its control", the authors said that the current ceRNA research is still in its infancy, each of ceRNA examples of types of studies are small. On the one hand, we need to find more types of ceRNA, on the other hand need to explore whether ceRNA cross is a universal dialogue, a large RNA transcriptional regulatory network.
Souce: NovoPro 2016-04-12