A research project by the Australian National University (ANU) led to life to fill the basic process - known as RNA-based recipe to build an important gap in understanding protein. The study published in "Nature" (Nature) magazine.
A research project by the Australian National University (ANU) led to life to fill the basic process - known as RNA-based recipe to build an important gap in understanding protein. The study published in "Nature" (Nature) magazine.
RNAs are short copy of the genetic information stored in DNA's. Ribosomes read them, these recipes will translate into life as a member of the main protein.
Lead researcher John Curtin Institute of Medical Research, Australian National University Professor Thomas Preiss said this new understanding for the treatment of a wide range of diseases, including cancer, heart disease and a range of relatively rare genetic disease has opened up new avenues.
Professor Preiss said: "When we first caught a life-critical processes running in the translation initiation process so that the world puzzled scientists for nearly 40 years."
The researchers captured a snapshot of how the ribosome along the RNA chain distribution, with particular attention to ensure that the ribosome starts reading the recipe from the correct starting point mechanism.
Body's cells in their DNA are included in the same full life blueprint. "To build and maintain the brain, bone or liver cells in a wide variety, on when, where and what kind of RNA used for the formulation requires great accuracy," Professor Preiss said.
Ribosome how to efficiently and accurately read and translate these formulations is also crucial. For example, it is known ribosome excessive activation in cancer.
Professor Preiss said: "We now apply our tools and insight, a better understanding of the process of tumor formation in their formulation of these RNA interactions, is expected to develop some new and better treatments."
This study confirms a theory for 40 years, explained the ribosome is how to properly find the starting point of this password. Study group members, Dr. Nikolay Shirokikh Australian National University, said the study explores the two elements of the ribosome start position RNA chain attached to.
Dr. Shirokikh said: "This theory, less than half portion of ribosomal RNA attaches itself to the starting point, and then along the RNA chain until it finds a scanning start signal of the recipe here, most part of the ribosome join. the entire ribosome start making proteins. "
"Our ribosome snapshot method ultimately provides evidence that the scan model is correct for the ribosome can more quickly accomplish these various tasks, other cellular elements of how all the way to help it, we also gained some new understanding. "
Souce: NovoPro 2016-07-22