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Product Name
ZIP kinase antibody
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Description
ZIP kinase Rabbit Polyclonal antibody. Positive IF detected in HeLa cells.
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Tested applications
ELISA, IF
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Species reactivity
Human; other species not tested.
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Alternative names
DAP kinase 3 antibody; DAP like kinase antibody; DAPK3 antibody; Dlk antibody; ZIP kinase antibody; ZIPK antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of Peptide (Accession Number: NM_001348). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
IF: 1:20-1:200
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Validations
Immunofluorescent analysis of (-20oc Ethanol) fixed HeLa cells using Catalog No:117059(DAPK3 Antibody) at dilution of 1:50 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Background
ZIP kinase, also named as ZIPK and Dlk, belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family and DAP kinase subfamily. ZIP kinase is a Serine/threonine kinase which acts as a positive regulator of apoptosis. ZIP kinasephosphorylates histone H3 on 'Thr-11' at centromeres during mitosis. ZIP kinase regulates myosin light chain phosphatase through phosphorylation of MYPT1 thereby regulating the assembly of the actin cytoskeleton, cell migration, invasiveness of tumor cells, smooth muscle contraction and neurite outgrowth. It catalyze the reaction: ATP + a protein = ADP + a phosphoprotein.
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