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Product Name
Recombinant YETS2 protein (His tag)
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Description
Recombinant YEATS2 (204-332) Fragment is a high-quality, soluble protein derived from the human YEATS domain-containing protein 2. This fragment is ideal for investigating chromatin regulation, specifically histone recognition and modifications, in structural and biochemical studies.
The full-length YEATS2 protein is a chromatin reader component of the ATAC complex, which possesses histone acetyltransferase activity targeting histones H3 and H4. It specifically binds to histone H3 crotonylated at Lys-27 (H3K27cr), a modification associated with active promoters and enhancers that confers resistance to transcriptional repressors. YEATS2 is localized in the nucleus, where it plays a critical role in epigenetic regulation and gene expression control.
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Protein name
YEATS domain-containing protein 2
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Uniprot ID
Q9ULM3
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Gene Name
YEATS2; KIAA1197
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 204-332 aa (Q9ULM3) were fused with C-terminal 6His tag.
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Sequence
MNHKVLFVKK TIVVGNVSKY IPPDKREEND QSTHKWMVYV RGSRREPSIN HFVKKVWFFL HPSYKPNDLV EVREPPFHLT RRGWGEFPVR VQVHFKDSQN KRIDIIHNLK LDRTYTGLQT LGAETVVDVE LHRHLEHHHH HH
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 17.01 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 17 kDa band.
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Purity
>85%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Validations
Recombinant YETS2 protein (His tag) SDS-PAGE
M: Marker; Lane 1: YETS2; Lane 2: BSA
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"