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Human CCN4/WISP1 (His Tag) recombinant protein

Cat.#: 502578

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Product Information

  • Product Name
    Human CCN4/WISP1 (His Tag) recombinant protein
  • Documents
  • Description
    Downstream regulator in the Wnt/Frizzled-signaling pathway. Associated with cell survival. Attenuates p53-mediated apoptosis in response to DNA damage through activation of AKT kinase. Up-regulates the anti-apoptotic Bcl-X(L) protein. Adheres to skin and melanoma fibroblasts. In vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycan.
  • Protein name
    WNT1-inducible-signaling pathway protein 1
  • Protein short names
    AW146261; WISP1TC; WISP1; WISP1I; ELM1; WISP1C; CCN4
  • Uniprot ID
    O95388
  • Gene Name
    WISP1; CCN4
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human WISP1 (NP_003873.1) (Met 1-Asn 367) was expressed with a C-terminal polyhistidine tag.
  • Protein Species
    Human
  • Molecular weight
    The secreted recombinant human WISP1 consisting of 356 amino acids has a calculated molecular mass of 39 kDa. As a result of glycosylation, It migrates as an approximately 55 kDa protein in SDS-PAGE under reducing conditions.
  • Purity
    > 95 % as determined by SDS-PAGE
  • Activity
    Measured in a cell proliferation assay using NRK-49F rat fibroblasts (Xu, L. et al., 2000, Gene and Dev. 14: 585.). The ED50 for this effect is typically 10-25 μg/ml.
  • Validations

    Human CCN4 / WISP1 Protein (His Tag) SDS-PAGE

    Human CCN4 / WISP1 Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"