Cart 2
  • VIP (6-28) (human, bovine, porcine, rat) peptide

VIP (6-28) (human, bovine, porcine, rat) peptide

Not For Human Use, Lab Use Only.

Cat.#: 301576

Size:

* Buy 1 get 1 free (?) What is TFA?

Special Price 225.00 USD

Availability: 3 weeks
- +

Add to cart to get an online quotation

Product Information

  • Product Name
    VIP (6-28) (human, bovine, porcine, rat) peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    FTDNYTRLRKQMAVKKYLNSILN-NH2
  • Sequence
    H-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2
  • Length (aa)
    23
  • Peptide Purity (HPLC)
    95.8%
  • Molecular Formula
    C126H207N37O34S
  • Molecular Weight
    2816.32
  • CAS No.
    69698-54-0
  • Source
    Synthetic
  • Form
    Powder
  • Description

    VIP (6-28) is a truncated form of vasoactive intestinal peptide (VIP) that acts as an effective antagonist at VIP receptors. This peptide fragment binds to VIP receptors without activating adenylate cyclase, thereby blocking the actions of endogenous VIP. In the rat superior cervical sympathetic ganglion (SCG), VIP (6-28) reduces the increase in cAMP levels produced by exogenous VIP and inhibits the VIP-stimulated elevation of VIP–PHI mRNA in neuron-enriched cultures.

    VIP (6-28) is specific in its antagonism, as it does not alter cAMP levels stimulated by other agents such as isoproterenol or forskolin. By blocking the actions of VIP released from injured sympathetic neurons in culture, VIP (6-28) significantly reduces the normal increase in VIP–PHI mRNA expression. This demonstrates that VIP, or a closely related molecule, produced by adult sympathetic neurons after injury can enhance its own expression through an autocrine or paracrine mechanism.

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • V.A.Fishbein et al., Peptides, 15, 95 (1994)
    • Mohney RP, Zigmond RE. Vasoactive intestinal peptide enhances its own expression in sympathetic neurons after injury. J Neurosci. 1998 Jul 15;18(14):5285-93. doi: 10.1523/JNEUROSCI.18-14-05285.1998. PMID: 9651211; PMCID: PMC6793472.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight

• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"