Vasoactive intestinal polypeptide, VIP, human, porcine, rat; VIP (28 amino acids)
Not For Human Use, Lab Use Only.
Cat.#: 312079
Optional Service:
TFA RemovalWhat's this?
Special Price 273.8 USD
Availability:
2-3 weeks
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Product Name
Vasoactive intestinal polypeptide, VIP, human, porcine, rat; VIP (28 amino acids)
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Documents
Batch to batch variation of the purity
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Sequence Shortening
HSDAVFTDNYTRLRKQMAVKKYLNSILN
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Sequence
His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn
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Length (aa)
28
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Peptide Purity (HPLC)
95.7%
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Molecular Formula
C147H238N44O42S
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Molecular Weight
3325.7
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Source
Synthetic
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Form
Powder
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Description
It showed a good activity against E. coli ATCC 25922 (MIC 5.2 ug/ml), P. aeruginosa ATCC 27853 (4.1 ug/ml), and moderate activity against C. albicans (MIC 46.5 ug/ml), very weak activity against S. mutans NCTC 10449 (MIC 150 ug/ml). Vasoactive intestinal polypeptide has Antibacterial, Antifungal activity. Vasoactive intestinal polypeptide was found in Homo sapiens.
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Storage Guidelines
Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
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References
- Mutt V, Said SI. Structure of the porcine vasoactive intestinal octacosapeptide. The amino-acid sequence. Use of kallikrein in its determination. Eur J Biochem. 1974;42(2):581-9.
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About TFA salt
Trifluoroacetic acid (TFA) has a significant impact on peptides due to its role in the peptide synthesis process.
TFA is essential for the protonation of peptides that lack basic amino acids such as Arginine (Arg), Histidine (His), and Lysine (Lys), or ones that have blocked N-termini. As a result, peptides often contain TFA salts in the final product.
TFA residues, when present in custom peptides, can cause unpredictable fluctuations in experimental data. At a nanomolar (nM) level, TFA can influence cell experiments, hindering cell growth at low concentrations (as low as 10 nM) and promoting it at higher doses (0.5–7.0 mM). It can also serve as an allosteric regulator on the GlyR of glycine receptors, thereby increasing receptor activity at lower glycine concentrations.
In an in vivo setting, TFA can trifluoroacetylate amino groups in proteins and phospholipids, inducing potentially unwanted antibody responses. Moreover, TFA can impact structure studies as it affects spectrum absorption.
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Molar Concentration Calculator
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Dilution Calculator
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Percent Concentration Calculator
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
Peptide Property
- Analysed Sequence:A
- Chemical Formula:A
- Sequence length:A
- Extinction coefficient:A M-1cm-1
- GRAVY:A
- Mw average:A
- Theoretical pI:A
- Data Source:Peptide Property Calculator
GRAVY = grand average of hydropathy
X: Hydrophobic uncharged residues, like F I L M V W A and P
X: Basic residues, like R K H
X: Acidic residues, like D E
X: Polar uncharged residues, like G S T C N Q and Y
Related Products / Services
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• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"