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Product Name
Vaccinia VACWR200/B18R recombinant protein
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Description
B18R, also known as B19R in the Copenhagen strain of Vaccinia, is a type I interferon (IFN)-binding protein encoded by the B18R open reading frame in the Western Reserve strain of vaccinia virus. B18R exists in two forms, soluble and membrane-bound form and also has a broad species specificity. B18R has high affinity for human IFN-alpha and also binds rabbit, bovine, rat, pig, and mouse IFN-alpha and IFN-beta. Secreted B18R binds to uninfected and infected cells. B18R presents at the cell surface and protects cells from the antiviral state. It has shown that binding of soluble recombinant B18R protects cultured cells from IFN and allows vaccinia virus replication.
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Protein name
temporal expression: early(B19R)
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Protein short names
B18R
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Uniprot ID
P25213
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the Vaccinia VACWR200/B18R His20-Glu351 is expressed with a 6His tag at the C-terminus.
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Protein Species
Vaccinia
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Purity
>95% as determined by SDS-PAGE.
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Validations
Vaccinia VACWR200/B18R recombinant protein
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