• Urumin peptide

Urumin peptide

Not For Human Use, Lab Use Only.

Cat.#: 319130

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Optional Service: TFA RemovalWhat's this?

Special Price 229.4 USD

Availability: 3 weeks
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Product Information

  • Product Name
    Urumin peptide
  • Documents
  • Sequence
    H-IPLRGAFINGRWDSQCHRFSNGAIACA-OH
  • Three letter code
    H-Ile-Pro-Leu-Arg-Gly-Ala-Phe-Ile-Asn-Gly-Arg-Trp-Asp-Ser-Gln-Cys-His-Arg-Phe-Ser-Asn-Gly-Ala-Ile-Ala-Cys-Ala-OH
  • Length (aa)
    27
  • Peptide Purity (HPLC)
    95.67%
  • Molecular Formula
    C129H198N42O35S2
  • Molecular Weight
    2961.33
  • Source
    Synthetic
  • Additional Information
    Urumin is a 27-amino acid virucidal host defense peptide, originally isolated from the skin of the South Indian frog Hydrophylax bahuvistara. Urumin is virucidal for H1 hemagglutinin bearing human influenza A viruses, in which it specifically targets the conserved stalk region of H1 hemagglutinin, and is effective against drug-resistant H1 influenza viruses that are resistant to oseltamivir, zanamivir and peramivir. Urumin appears to inhibit viral growth by physically destroying influenza virions, and can also protect naive mice from lethal influenza infection in vivo.
  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
  • References
    • Holthausen et al (2017) An Amphibian Host Defense Peptide Is Virucidal for Human H1 Hemagglutinin-Bearing Influenza Viruses. Immunity 46(4) 587 PMID: 28423338
  • About TFA salt

    Trifluoroacetic acid (TFA) is a strong acid, which is commonly used to cleave synthesized peptides from solid-phase resins and is also used to improve HPLC performance in the peptide purification step. By default, custom peptides are delivered as lyophilized TFA salts, and can contain as much as 10-45% TFA.

    TFA in custom peptides can cause inexplicable discrepancies in subsequent assay data. For instance, TFA in nM concentrations has been shown to interfere with cellular assays, inhibiting cellular proliferation in some instances, and increasing cell viability in others . It has also been found to be an unintended allosteric modulator of the glycine receptor, GlyR.

    TFA Removal Service is recommended for:

    • Peptides that will be used in cellular assays
    • Peptides that will be used as APIs or in manufactured products
    • For hydrophilic peptides containing numerous basic residues

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Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"