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Product Name
URAT1 antibody
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Description
URAT1 Rabbit Polyclonal antibody. Positive WB detected in PC-13 cells, HEK-293 cells, HepG2 cells, human kidney tissue. Observed molecular weight by Western-blot: 65-70 kDa or 40 kDa
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Tested applications
ELISA, WB
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Species reactivity
Human, Mouse; other species not tested.
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Alternative names
OAT4L antibody; OATL4 antibody; Renal specific transporter antibody; RST antibody; SLC22A12 antibody; URAT1 antibody; Urate anion exchanger 1 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of URAT1 recombinant protein (Accession Number: NM_144585). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
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Validations
PC-13 cells were subjected to SDS PAGE followed by western blot with Catalog No:116640(URAT1 antibody) at dilution of 1:600
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Background
Human urate anion exchanger (URAT1), also known as SLC22A12, is a urate transporter located in the proximal tubules of human kidney and responsible for urate reabsorption. Defects in gene encoding URAT1 cause hypouricemia renal type 1 (RHUC1). This antibody recognizes the native and glycosylated URAT1 between 65 and 70 kDa as well as the truncated 40kDa protein.
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References
- Wu X, Zhang J, Liu T. Uric acid crystal could inhibit Numb-induced URAT1 lysosome degradation in uric acid nephropathy. Journal of physiology and biochemistry. 71(2):217-26. 2015.
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