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UPK3B antibody

Cat.#: 116631

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Special Price 239.0 USD

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Product Information

  • Product Name
    UPK3B antibody
  • Documents
  • Description
    UPK3B Rabbit Polyclonal antibody. Positive IHC detected in human bladder tissue. Positive IP detected in mouse testis tissue. Observed molecular weight by Western-blot: 34 kDa
  • Tested applications
    ELISA, IHC, IP
  • Species reactivity
    Human, Mouse; other species not tested.
  • Alternative names
    FLJ32198 antibody; P35 antibody; UP3b antibody; UPIIIb antibody; UPK3B antibody; uroplakin 3B antibody; Uroplakin IIIb antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of UPK3B recombinant protein (Accession Number: BC004304). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    IP: 1:200-1:1000

    IHC: 1:20-1:200

  • Validations

    IP Result of anti-UPK3B (IP:Catalog No:116631, 2ug; Detection:Catalog No:116631 1:300) with mouse testis tissue lysate 4000ug.

    IP Result of anti-UPK3B (IP:Catalog No:116631, 2ug; Detection:Catalog No:116631 1:300) with mouse testis tissue lysate 4000ug.

    Immunohistochemistry of paraffin-embedded human bladder tissue slide using Catalog No:116631(UPK3B Antibody) at dilution of 1:100 (under 10x lens)

    Immunohistochemistry of paraffin-embedded human bladder tissue slide using Catalog No:116631(UPK3B Antibody) at dilution of 1:100 (under 10x lens)

    Immunohistochemistry of paraffin-embedded human bladder tissue slide using Catalog No:116631(UPK3B Antibody) at dilution of 1:100 (under 40x lens)

    Immunohistochemistry of paraffin-embedded human bladder tissue slide using Catalog No:116631(UPK3B Antibody) at dilution of 1:100 (under 40x lens)

  • Background
    Uroplakins are a group of urothelial differentiation-related membrane proteins. They are components of the asymmetric unit membrane (AUM), which forms the apical plaques of mammalian urothelium and is believed to play a role in strengthening the urothelial apical surface thus preventing the cells from rupturing during bladder distention (PMID: 8175808). Uroplakin-3b (UPK3B), also named as p35, is a single-pass type I membrane protein. This protein dimerizes with uroplakin-1b (UPK1B) to exit out of endoplasmic reticulum, which is is an important early step in urothelial plaque assembly (PMID: 12446744).

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"