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Product Name
UPK2-Specific antibody
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Description
UPK2-Specific Rabbit Polyclonal antibody. Positive IHC detected in human bladder tissue.
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Tested applications
ELISA, IHC
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Species reactivity
Human; other species not tested.
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Alternative names
UP2 antibody; UPII antibody; upk 2 antibody; UPK2 antibody; uroplakin 2 antibody; Uroplakin II antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of Peptide (Accession Number: NM_006760). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
IHC: 1:20-1:200
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Validations
Immunohistochemistry of paraffin-embedded human bladder tissue slide using Catalog No:116630(UPK2-Specific Antibody) at dilution of 1:200 (under 10x lens)
Immunohistochemistry of paraffin-embedded human bladder tissue slide using Catalog No:116630(UPK2-Specific Antibody) at dilution of 1:200 (under 40x lens)
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Background
Uroplakins are a group of urothelial differentiation-related membrane proteins. They are components of the asymmetric unit membrane (AUM), which forms the apical plaques of mammalian urothelium and is believed to play a role in strengthening the urothelial apical surface thus preventing the cells from rupturing during bladder distention (PMID: 8175808). Uroplakin-2 (UPK2) is a single-pass type I membrane protein. UPK2 may play an important role in regulating the assembly of the AUM.
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