-
Product Name
Rhesus CLP1 / COLEC12 (His Tag) recombinant protein
- Documents
-
Description
CLP1, also known as COLEC12, is a scavenger receptor that displays several functions associated with host defense. It contains 1 C-type lectin domain and 3 collagen-like domains. CLP1 is strongly expressed in placenta and moderately expressed in heart, skeletal muscle, small intestine and lung. It promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. CLP1 mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. It binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. It binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR). CLP1 may also play a role in the clearance of amyloid beta in Alzheimer disease.
-
Protein name
Uncharacterized protein
-
Protein short names
SCARA4; HCL-P1; NURSE CELL SCAVENGER RECEPTOR 2; COLLECTIN PLACENTA PROTEIN 1; CLP1; CL-P1; SRCL; MEMBER 4; NSR2; SCAVENGER RECEPTOR WITH C-TYPE LECTIN; SCAVENGER RECEPTOR CLASS A; COLLECTIN-12
-
Uniprot ID
F6RUR9
-
Gene Name
COLEC12
-
Source/Expression Host
Baculovirus-Insect Cells
-
Expression Plasmid/cDNA
A DNA sequence encoding the rhesus COLEC12 (F6RUR9) (Ala37-Leu678) was expressed with a polyhistide tag at the N-terminus.
-
Protein Species
Rhesus
-
Molecular weight
The recombinant rhesus COLEC12 comprises 658 amino acids and has a calculated molecular mass of 72.3 KDa.
-
Purity
> 95 % as determined by SDS-PAGE
-
Validations
Cynomolgus CLP1 / COLEC12 Protein (His Tag) SDS-PAGE
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"