Human Pleckstrin / PLEK / p47 (His Tag) recombinant protein

Human Pleckstrin / PLEK / p47 (His Tag) recombinant protein

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Pleckstrin is a protein found in platelets. Pleckstrin is the source of the name pleckstrin homology domain. Pleckstrin homology domain (PH domain) is a protein domain of approximately 120 amino acids that occurs in a wide range of proteins involved in intracellular signaling or as constituents of the cytoskeleton. This domain can bind Phosphatidylinositol lipids within biological membranes (such as Phosphatidylinositol (3,4,5)-trisphosphate and phosphatidylinositol (4,5)-bisphosphate), and proteins such as the βγ-subunits of heterotrimeric G proteins, and protein kinase C. Through these interactions, PH domains play a role in recruiting proteins to different membranes, thus targeting them to appropriate cellular compartments or enabling them to interact with other components of the signal transduction pathways.

Uncharacterized protein

RP23-348N2.1; P47; PLATELET 47 KDA PROTEIN; 2010300B13RIK; PLEK; PLECKSTRIN

G3RWG4

PLEK

E. coli

A DNA sequence encoding the mature form of human PLEK (XP_004029394.1) (Met1-Lys350) was expressed with a polyhistide tag at the N-terminus.

Human

The recombinant human PLEK consists of 365 amino acids and predicts a molecular mass of 41.9 KDa. It migrates as an approximately 45 KDa band in SDS-PAGE under reducing conditions.

> 95 % as determined by SDS-PAGE